Synthesis and characterization of new compounds of amic acids derived from cephalosporins, the study of some physical applications and evaluation of their biological activity

In this research, amino acids were prepared from the reaction of cephalosporins with anhydrous acids, and accuracy compositions was confirmed by measuring their physical properties, including melting point, molecular weight colour, as well through spectroscopic measurements, Uv, FTIR, 1H-NMR, 13C-NMR, mass spectrometry, (S.E.M.), (C.H.N.). A study electrical conductivity a survey biological activity some compounds on four types pathogenic bacteria, two which are Gram-positive, Gram-negative. They each (Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumonia, Pseudomonas putida). The use Acker-Hinton's type culture medium (Molar Hunting Agar) aqueous solutions [DM7] also prepared. [DM3] in concentrations (0.01,0.001,0. 0001,0.00001) mg/ml using solvent dimethyl sulfoxide (DMSO), sensitivity test conducted for bacteria isolates that used diffusion method, antibiotics Cefixime, Ceftriaxone, Ampicillin control sample.